About Our Research

The Hunter Lab, at the Salk Institute, is interested in the molecular mechanisms underlying growth control in cells and the regulation of progression through the cell cycle. They are studying the activation of growth factor receptors (frequently protein-tyrosine kinases, PTKs) and the signaling pathways that they activate, in turn. Their work on protein-tyrosine phosphatases (PTP), also involved in cell signaling, has shown that regulation of PTPs’ activity may be exactly opposite to that of PTKs.

The team’s research into the molecular bases of cell cycle regulation in mammals focuses on the substrates and inhibitors of specific kinases. They have identified a spindle-associated protein (Prc1) as a substrate of the cyclin-dependent kinases and described its action in the process of cell division.