Hunter Lab - Salk Institute
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1 News 502 Publications 18 Members

Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression.

Ma, Hui Han, Bong-Kwan Guaderrama, Marisela Aslanian, Aaron Yates, John R 3rd Hunter, Tony Wittenberg, Curt

Published in Molecular and cellular biology

The reversible nature of protein phosphorylation dictates that any protein kinase activity must be counteracted by protein phosphatase activity. How phosphatases target specific phosphoprotein substrates and reverse the action of kinases, however, is poorly understood in a biological context. We address this question by elucidating a novel function...

Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells

Aslanian, Aaron Yates, John R. III Hunter, Tony

Published in DNA Repair

Faithful transmission of genetic material is essential for cell viability and organism health. The occurrence of DNA damage, due to either spontaneous events or environmental agents, threatens the integrity of the genome. The consequences of these insults, if allowed to perpetuate and accumulate over time, are mutations that can lead to the develop...

Translating experience: thinking outside the box.

Hunter, Tony

Published in Nature cell biology

The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination.

Lu, Chi-Sheng Truong, Lan N Aslanian, Aaron Shi, Linda Z Li, Yongjiang Hwang, Patty Yi-Hwa Koh, Kwi Hye Hunter, Tony Yates, John R 3rd Berns, Michael W ...

Published in The Journal of biological chemistry

Ubiquitination plays an important role in the DNA damage response. We identified a novel interaction of the E3 ubiquitin ligase RNF8 with Nbs1, a key regulator of DNA double-strand break (DSB) repair. We found that Nbs1 is ubiquitinated both before and after DNA damage and is a direct ubiquitination substrate of RNF8. We also identified key residue...

The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models.

Wang, Zhiyong Shah, O Jameel Hunter, Tony

Published in PloS one

Three p160 family members, p/CIP, SRC1, and TIF2, have been identified as transcriptional coactivators for nuclear hormone receptors and other transcription factors in vitro. In a previous study, we reported initial characterization of the obesity-resistant phenotypes of p/CIP and SRC-1 double knockout (DKO) mice, which exhibit increased energy exp...

Protein kinase signaling networks in cancer.

J, Brognard T, Hunter

Published in Current Opinion in Genetics & Development

Protein kinases orchestrate the activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. The complexity of numerous intracellular signaling pathways is highlighted by the number of kinases encoded by the human genome (539) and the plethora of phosphorylation sites i...

Genetic and cellular mechanisms of oncogenesis: Editorial overview

Tony Hunter Marais, R

Published in Current Opinion in Genetics & Development

Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenes...

Ys, Yoon Mw, Lee D, Ryu Jh, Kim H, Ma Wy, Seo Yn, Kim Ss, Kim Ch, Lee T, Hunter ...

Published in Proceedings of the National Academy of Sciences

Fasting promotes hepatic gluconeogenesis to maintain glucose homeostasis. The cAMP-response element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) is responsible for transcriptional activation of gluconeogenic genes and is critical for conveying the opposing hormonal signals of glucagon and insulin in the liver. Here, we sho...

Regulation of the cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex

Olson, B J S C Oberholzer, M Li, Y Zones, J M Kohli, H S Bisova, K Fang, S C Jill Meisenhelder Tony Hunter Umen, J G ...

Published in Plant and Cell Physiology

CtIP links DNA double-strand break sensing to resection.

You, Zhongsheng Shi, Linda Z Zhu, Quan Wu, Peng Zhang, You-Wei Basilio, Andrew Tonnu, Nina Verma, Inder M Berns, Michael W Hunter, Tony ...

Published in Molecular cell

In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA that is essential for activation of the DNA damage checkpoint and DNA repair by homologous recombination (HR). However, the biochemical mechanism underlying the transition from DSB ...

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