Crosstalk between the ubiquitin and SUMO pathways

Tony Hunter: kinase king. Interview by Ruth Williams.

Published in The Journal of Cell Biology

Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stabil...

Published in Molecular and cellular biology

The minichromosome maintenance (MCM) complex plays essential, conserved roles throughout DNA synthesis: first, as a component of the prereplication complex at origins and, then, as a helicase associated with replication forks. Here we use fission yeast (Schizosaccharomyces pombe) as a model to demonstrate a role for the MCM complex in protecting re...

Instructive role of aPKCz subcellular localization in the assembly of adherens junctions in neural progenitors

Crosstalk between the SUMO and ubiquitin pathways

Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells.

Published in The Journal of Cell Biology

To determine how extracellular signal-regulated kinases (ERK) 1/2 promote mammary tumorigenesis, we examined the real-time behavior of cells in an organotypic culture of the mammary glandular epithelium. Inducible activation of ERK1/2 in mature acini elicits cell motility and disrupts epithelial architecture in a manner that is reminiscent of ducta...

A not so brief history of the Oncogene Meeting and its cartoons

Published in Oncogene

Akt inhibitor A-443654 induces rapid Akt Ser-473 feedback phosphorylation independent of mTORC1 inhibition

Published in Oncogene

Essential role of Tuberous Sclerosis Complex genes TSC1/2 in NF-B activation and cell survival

Published in Cancer Cell International

MEKK1: dual function as a protein kinase and a ubiquitin protein ligase