Crosstalk between the SUMO and ubiquitin pathways

Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells.

Published in The Journal of Cell Biology

To determine how extracellular signal-regulated kinases (ERK) 1/2 promote mammary tumorigenesis, we examined the real-time behavior of cells in an organotypic culture of the mammary glandular epithelium. Inducible activation of ERK1/2 in mature acini elicits cell motility and disrupts epithelial architecture in a manner that is reminiscent of ducta...

A not so brief history of the Oncogene Meeting and its cartoons

Published in Oncogene

Akt inhibitor A-443654 induces rapid Akt Ser-473 feedback phosphorylation independent of mTORC1 inhibition

Published in Oncogene

Essential role of Tuberous Sclerosis Complex genes TSC1/2 in NF-B activation and cell survival

Published in Cancer Cell International

MEKK1: dual function as a protein kinase and a ubiquitin protein ligase

Cyclin-dependent kinase (CDK) phosphorylation destabilizes Wee1A via multiple pathways

Wnt-independent -catenin transactivation in tumor development

Published in Cell Cycle

Inappropriate activation of the TSC

Published in Current Biology

Unexpected mediators of protein phosphorylation

Published in Science