Hunter Lab - Salk Institute
  • Upload

  • Log in

  • Sign up

Search on MyScienceWork
1 News 502 Publications 18 Members

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism.

Xinde Zheng Tony Hunter

Published in Cell Research

Pink1, a mitochondrial kinase, and Parkin, an E3 ubiquitin ligase, function in mitochondrial maintenance. Pink1 accumulates on depolarized mitochondria, where it recruits Parkin to mainly induce K63-linked chain ubiquitination of outer membrane proteins and eventually mitophagy. Parkin belongs to the RBR E3 ligase family. Recently, it has been prop...

  • ← Previous
  • 1
  • …
  • 47
  • 48
  • 49
  • 50
  • 51 (current)
  • Next →
Powered by Polaris
  • About the Lab
  • Our Research
  • FAQ