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Rapid activation of ATM on DNA flanking double-strand breaks.

You, Z Bailis, Jm Johnson, Sa Dilworth, Sm Tony Hunter

Published in Nature Cell Biology

The tumour-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia (A-T), encodes a key protein kinase that controls the cellular response to DNA double-strand breaks (DSBs). DNA DSBs caused by ionizing radiation or chemicals result in rapid ATM autophosphorylation, leading to checkpoint activation and phosphor...

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