In vitro polyoma DNA synthesis: asymmetry of short DNA chains
Published in Cell
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
...Published in Cell
Tumor-specific pyruvate kinase M2 (PKM2) is essential for the Warburg effect. In addition to its well-established role in aerobic glycolysis, PKM2 directly regulates gene transcription. However, the mechanism underlying this nonmetabolic function of PKM2 remains elusive. We show here that PKM2 directly binds to histone H3 and phosphorylates histone...
Protein tyrosine phosphatases in the human genome.
...Published in Cell
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role...
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates
Published in Cell
Evidence that phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus
Published in Cell
Characterization of T antigens in polyoma-infected and transformed cells
Published in Cell
Protein-tyrosine phosphatases: the other side of the coin
Published in Cell
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cell...
Published in Cell
SMK-1, an essential regulator of DAF-16-mediated longevity.
Published in Cell
Insulin/IGF-1 signaling (IIS) regulates aging in worms, flies, and mice through a well-characterized, highly conserved core set of components. IIS also regulates early developmental decisions, the reproductive status of the animal, innate immunity, and stress-resistance functions. In C. elegans, the sole insulin/IGF-1 receptor, DAF-2, negatively re...
Phospholipase C-g is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
Published in Cell
