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Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells

Aslanian, Aaron Yates, John R. III Hunter, Tony

Faithful transmission of genetic material is essential for cell viability and organism health. The occurrence of DNA damage, due to either spontaneous events or environmental agents, threatens the integrity of the genome. The consequences of these insults, if allowed to perpetuate and accumulate over time, are mutations that can lead to the develop...

Monitoring ATM kinase activity in living cells.

Johnson, Sa You, Z Tony Hunter

Published in DNA Repair

DNA double strand breaks (DSB) in mammalian cells result in the activation of the ATM protein kinase. This leads to phosphorylation of numerous downstream transducer and effector proteins that coordinate a cellular response including DNA repair, cell cycle arrest or apoptosis. We have developed a reporter protein that allows the measurement of ATM ...

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Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells

Monitoring ATM kinase activity in living cells.