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Discovering the first tyrosine kinase.

Hunter, Tony

Published in Proceedings of the National Academy of Sciences of the United States of America

In the middle of the 20th century, animal tumor viruses were heralded as possible models for understanding human cancer. By the mid-1970s, the molecular basis by which tumor viruses transform cells into a malignant state was beginning to emerge as the first viral genomic sequences were reported and the proteins encoded by their transforming genes w...

Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenes...

Yoon, Young-Sil Lee, Min-Woo Ryu, Dongryeol Kim, Jeong Ho Ma, Hui Seo, Woo-Young Kim, Yo-Na Kim, Su Sung Lee, Chul Ho Hunter, Tony ...

Published in Proceedings of the National Academy of Sciences of the United States of America

Fasting promotes hepatic gluconeogenesis to maintain glucose homeostasis. The cAMP-response element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) is responsible for transcriptional activation of gluconeogenic genes and is critical for conveying the opposing hormonal signals of glucagon and insulin in the liver. Here, we sho...

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