Hunter Lab - Salk Institute
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Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension.

Woodring, Pj Litwack, Ed O Leary, Dd Lucero, Gr Wang, Jy Tony Hunter

Published in The Journal of Cell Biology

The nonreceptor tyrosine kinase encoded by the c-Abl gene has the unique feature of an F-actin binding domain (FABD). Purified c-Abl tyrosine kinase is inhibited by F-actin, and this inhibition can be relieved through mutation of its FABD. The c-Abl kinase is activated by physiological signals that also regulate the actin cytoskeleton. We show here...

Tony Hunter: kinase king. Interview by Ruth Williams.

T, Hunter

Published in The Journal of Cell Biology

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading.

Woodring, Pj Jill Meisenhelder Johnson, Sa Zhou, Gl Field, J Shah, K Bladt, F Pawson, T Niki, M Pandolfi, Pp ...

Published in The Journal of Cell Biology

Filopodia are dynamic F-actin structures that cells use to explore their environment. c-Abl tyrosine kinase promotes filopodia during cell spreading through an unknown mechanism that does not require Cdc42 activity. Using an unbiased approach, we identified Dok1 as a specific c-Abl substrate in spreading fibroblasts. When activated by cell adhesion...

PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone.

Mollinari, C Kleman, Jp Jiang, W Schoehn, G Tony Hunter Margolis, Rl

Published in The Journal of Cell Biology

Midzone microtubules of mammalian cells play an essential role in the induction of cell cleavage, serving as a platform for a number of proteins that play a part in cytokinesis. We demonstrate that PRC1, a mitotic spindle-associated Cdk substrate that is essential to cell cleavage, is a microtubule binding and bundling protein both in vivo and in v...

Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells.

Gw, Pearson T, Hunter

Published in The Journal of Cell Biology

To determine how extracellular signal-regulated kinases (ERK) 1/2 promote mammary tumorigenesis, we examined the real-time behavior of cells in an organotypic culture of the mammary glandular epithelium. Inducible activation of ERK1/2 in mature acini elicits cell motility and disrupts epithelial architecture in a manner that is reminiscent of ducta...

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